"Well, if you literally just drop half a ton of rock on a vampire it usually sticks. Not always, you're a very compressible species, but if you're reduced to paste it's a safe bet. In that vein there's also wrecking balls, large vehicles, dropping from skyscrapers, massive explosions... oh, fire works too. I should mention that I didn't test all this myself, I stick to head-removal and fire mostly, but my mom was very thorough with her experimentation. Vicious woman she was. She had a heart of gold, but she had claws too. Quite literally."